The Wheels Came Off

I came across this just a few days ago. I was checking for (any) precedent for an expression I learnt at school (as you will see at the end of this blog). “The Wheels Come Off” means “things go disastrously wrong; a situation devolves into ruin or chaos” which we can use these days for just about everything in the news these days. Politics, climate change, you name it – was it ever as bad as it is now?

Yes, but we focus on the now, as ever forgetting the past. And no, I am not going to repeat what you also have read in the news this week. The “now” has much to enjoy in fact. Tomorrow I and possibly hundreds of others celebrate the first birthday of Bobbie, my first grandchild. What a joy she is! And she together with her generation inherits a world so far from the one I first enjoyed. My first (eleven) years were in a sleepy mid-England village for which I am O so grateful. Then six or more years in Norfolk, just as sleepy before my eight years in Leeds. Step by step I moved from rural bliss to the “real world”. Bobbie already lives in a city (OK The Hague is also a little quiet) and kids today seem very able to handle city life and all it brings.

So why the title to this blog? Back to Norfolk and my years at Hamonds Grammar School in Swaffham. Some of my classmates were both ingenious and amusing. Every day a master would use a complicated word which, at the time, we did not understand. Then one of my mates came up with the expression “I used to have one of  them but the wheels came off”!

Bobbie, be happy and enjoy this world. Don’t worry about the wheels!

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Sticky People

This last week I have removed (deleted) more than 5,000 Emails dating back to 2011. At last I found the courage to clean-up my mailbox and hopefully keep it that way. No longer can I, nor want to, dwell on what is passed and what people have written. Inspired, I then cut my Contacts list from over 500 down to 300 or so. Also therapeutic. Some people sadly had passed away in the last 8 years but the rest of the people I “deleted” I can only describe as “sticky”. They cling on to you but never do what you had hoped they would, instead just wasting my time.

Since 2004 I have led a Foundation to bring creativity to young people (Kids and Science) but no longer. Sadly, while becoming used to sticky people getting in the way and delivering nothing, it became clear that most young people no longer want to put that much effort into anything that takes their valuable time. OK to put on a T-shirt, take a day off school and march in support of the environment. But do anything more, that’s out of the question.

My efforts to provide chemistry research scientists with quality synthetic information introduced me to hoards of sticky people. Each in their own way wore down my energy until it became clear that this was no longer a viable business operation. And so the list goes on. I would now argue that the best way to kill something is to say you support it and then do nothing. If so, you have no longer a place in my PC…

Is this the positive Dick who went after every good idea only to reach that wall of indifference from sticky people? Yes. Will he now change? I certainly hope so! Oh and I am possibly the most sticky person you will ever know – really. I attract and carry for years people who appear to want to be carried, or so they think. My deleted contacts are testimony yo this.

And no, I am not bitter or depressed about this. I can now move on without that baggage and that makes me feel very good. Every now and then, I open my heart in my blog and this I have done today. If you suffer from sticky people, think about deleting them (on your computer, that is!)

 

 

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Keeping The Conch

Well, Yes, You Know…Umm…Err… And it is getting worse! The radio/TV interview where the microphone is dominated by someone who, at the time, has no idea what to say. Not so long back, there was a slight pause (maybe one or two seconds) between the question and the begin of a considered reply. I still value this. But today it seems rather old-fashioned – better to grab attention and keep on talking.

English is a fine language but currently served American-style. Fast. Also here in the Netherlands, the start of the reply is umming and ahhing until the ideas appear. This is particularly true for skaters or cyclists who need catch their breath – but that is apparently fatal. This morning a good friend agreed and called it “keeping the conch”, referring to the book by William Golding and the subsequent film (1963) Lord of the Flies. On YouTube you can still watch the entire film, albeit in poor resolution. The central characters are young boys who soon become “wild” on the small desert island until their rescue. Piggy and Ralph are the central characters who fight to retain (keep) the conch, a large seashell which becomes the symbol of power.

In these Brexit times, as well as across the globe where tyrants must keep talking to avoid attack, the conch is what you cannot afford to lose. If you pause, people might start to ask awkward questions. Start talking and keep talking and fill your sound-bite. Dominate is there is someone else being interviewed. Keep the conch!

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More Than Just Numbers

Under the stairs in the school house at Shelsley was a large cupboard full of interesting memorabilia, notably what my dad had from his army years. At the end of WW II he had become a major and soon I found his hat, swagger stick (which I still have) and a bugle. There was also a gun holster but no gun inside (thankfully). He best discovery was his slide rule and, patient man that he was, he taught me how to use it.

Slide rule.

It was described as a “mechanical analog computer” so I guess the abacus was the very first analog computer when you think about it. I have only a dim recollection of how the slide rule worked but I played with it for several years. I wondered whether my dad had used it to target g=his guns (he was in the Royal Artillery) but I never got round to asking him. The Wikipedia article describes what a slide rule can and cannot do, but at school we had moved on to log tables for calculations. Later, in 1973 I was at University College London on my first PostDoc and together with a few others I was asked to tutor some students for a term. My reward was some £80 which I (and also a few colleagues) used to buy our first Sinclair pocket calculators.

Oh the excitement! Today that £80 is worth €1100 ($1200) but in 1973 it was worth its weight in gold. And you needed a lot of gold to buy the batteries which had a very short life – but you did have a new toy! (Sir) Clive Sinclair was a remarkable man. He was a self-taught pioneer in electronics and the first on the market with (at the time) very imaginative new gadgets. Much of what he dreamt up and brought to the marketplace was soon replicated by the larger science-based companies. Much later I would buy a Seiko watch with a calculator function with input from figures your provided by your finger on the screen. Of course, this was just a gimmick.

Perhaps the craziest Sinclair invention was his battery driven car. It was largely invisible to trucks and there were many accidents. Here in the Netherlands there are hundreds of bicycles where the cyclist lies almost horizontal – but here there are cycle lanes and all drivers live in fear of hurting a cyclist.

  

Now let’s end in the early 80’s with my Texas Instruments scientific calculator which was so hip that you wanted everyone to see you had one. There was even a special pouch which you could attach to your belt and allow a few centimetres to be visible under your jacket! This picture is all I could find of this pouch and a pouch user – the gun-holster similarity is rather obvious here.

  

If you Google Clive Sinclair you will pick up quite a few stories of his private life which was far from dull. He was ahead of his time in so many ways and yet also very wary of the Internet and not a user of Email. He was about more than just numbers…

 

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More Incomplete

A couple of times I have mentioned the psychologist who uttered those immortal words “have the courage to be incomplete”. Now take a look at me aged around five trying to please everyone, as I always did for all those years.

After we moved to Norfolk, I started to take sport seriously, mainly running (cross country). I began to enjoy it. Each year my school held the cross country race for all age groups and I trained hard to be successful in mine. Then the day came. Several hundred boys raced across the football field towards the gateway leading to the lane, the begin of the race. As we all converged, someone trod on my left gym shoe and it came off. Panic! What to do? Stop and put it on again as fast as possible or run on with one shoe. I stopped, put the shoe on but by then I was almost last. But I was complete.

I would get back to running some 20 years later but I did not enjoy it that much. By then I was a research chemist and fascinated by molecular structures. I also found time to let my imagination run loose which I can best illustrate by my very own theory to get from A to B without running. Imagine being at the equator where the circumference of the Earth is 40,075 km. One day lasts 24x60x60 (86,400 seconds) So the Earth is spinning at 463 m/sec. Now imagine jumping in the air for one second. You should land 463 m to the west of where you jumped. Simple. Traveling to the east is of course a big problem… The speed of sound is 343 m/sec so my 463 m jump also produces a a large bang.

Now that we are all so concerned with climate change and conservation, there must be a Nobel Prize any day now for such a contribution as mine. Unless of course you insist in going east…

It has been in my head for some time now. No-Do-Day: a special day you reserve for when you will not do things. For a lot of people, this is a Monday. The weekend behind you and all those silly meetings at work you are meant to go to. Fridays also suffer from thoughts about what the weekend might bring. Go on, try it out! You will be amazed how happy you become. If you are a Civil Servant of course you have done this already for most of your career. No-Do-Days are also part of the being incomplete therapy.

Ever thought about not raising pigs? No, not one of mine but well worth reading.

 

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Milking Cows

No, I have never milked a cow. But read on… A quick check in Wikipedia taught me the basics about milking cows: To maintain lactation, a dairy cow must be bred and produce calves. Depending on market conditions, the cow may be bred with a “dairy bull” or a “beef bull.” Female calves (heifers) with dairy breeding may be kept as replacement cows for the dairy herd. If a replacement cow turns out to be a substandard producer of milk, she then goes to market and can be slaughtered for beef. Male calves can either be used later as a breeding bull or sold and used for veal or beef.

Some months ago I stopped eating meat and this only tells me that it was really necessary! But the whole cow milking industry can only be described as a carefully organised conditioning and grooming – the cows can be milked several times a day “because they like it”. In these LGBT times, I start to wonder about the Dutch Milkmaids who always look so happy…

But there are other cows than dairy cows. First take a look at academics and how they live of the taxpayers money until they hit their won (personal) jackpot. I thank my old Shell colleague (Mike) for sending me this. This is just the latest example of the rip-off; you live off government grants and funding until you hit big time. And you stuff the cash in your pocket! And it seems OK since the funding authorities never think about demanding their share of the booty. Naïve? No, plain stupid.

For 50 years I have been a synthetic organic chemist – and in this time I learned a lot about my fellow chemists – they are chaotic! They cannot organise their own publications so they accept the pariahs who call themselves publishers and rip off the scientists. George Monbiot is a Guardian columnist and he wrote this recently which really deserves your attention!

 (Look at what) Alexandra Elbakyan has done to the multibillion-dollar industry that traps knowledge behind paywalls. Sci-Hub, her pirate web scraper service, has done more than any government to tackle one of the biggest rip-offs of the modern era: the capture of publicly funded research that should belong to us all.

The model was pioneered by the notorious conman Robert Maxwell. He realised that, because scientists need to be informed about all significant developments in their field, every journal that publishes academic papers can establish a monopoly and charge outrageous fees for the transmission of knowledge. He called his discovery “a perpetual financing machine”. He also realised that he could capture other people’s labour and resources for nothing. Governments funded the research published by his company, Pergamon, while scientists wrote the articles, reviewed them and edited the journals for free. His business model relied on the enclosure of common and public resources. Or, to use the technical term, daylight robbery.

Half the world’s research is published by five companies: Reed Elsevier, Springer, Taylor & Francis, Wiley-Blackwell and the American Chemical Society. Libraries must pay a fortune for their bundled journals, while those outside the university system are asked to pay $20, $30, sometimes $50 to read a single article.

Elsevier says, “If you think information shouldn’t cost anything, go to Wikipedia”, inadvertently reminding us of what happened to the commercial encyclopedias.

Brilliant! My opinion on Elsevier I have already used in several blogs but their inadvertent acknowledgement of Wikipedia really amuses me. And Maxwell, that evil instigator of “a perpetual financing machine” has now his own special place in Hell.

Yes, to get rich quickly go and milk scientists – they will stay bent over for as long as you want them to. I know, I let it happen to me! 50 years ago I was a young ambitious and naïve chemist wanting to become a professor one day. After my PhD at Leeds, I did 2 years PostDoc in London (UCL) and 15 months at Columbia (New York). Only there did I discover the real world of scientific milking, leading to the ratrace to get tenure (most often not!) I wanted to take a look at my very first publication where I was so proud – “o-Quinonoid compounds. Part VII. 1,4-Diphenyl-2,3-naphthoquinone” published by the UK Chemical Society in 1970. On Google I kept hitting the paywalls – pay or you see nothing. I was not happy.

So how about some other milkmaids? Netflix is the giants (milker) right now. And this week HBO came to their last episode of Game Of Thrones – after 5 years! Every week, millions of people world-wide tuned in for the next episode – incredible (and so sad). I refuse to watch any TV program where “next week the story continues”. I am not a cow! Let me leave the final words to a Russian: “In June 2016, Russian Minister of Culture Vladimir Medinsky asserted that Netflix is part of a US government plot to influence the world culture, “to enter every home, get into every television, and through that television, into the head of every person on earth”.

I could not have said it better myself!

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My Dad And His Dad

My Dad’s name was Archibald Ronald and his Dad (my grandfather) was Archibald Jeremiah. My good fortune was not also be called Archie. Somewhere in my cellar there is a box of old photographs and one day I will have the courage to sort through them looking for my grandfather. He was a man of (very) few words and very kind. The name “Archibald” has quite a history. It means “genuine” or “precious” and bald “bold” but my memory was coloured (not in a nice way) by the BBC Radio programme Educating Archie.

It was a big hit for ten years (1950 – 1960) and featured Peter Brough (a ventriloquist) and his puppet (Archie). Some feat – a ventriloquist in a radio programme! Archie’s tutors included Tony Hancock, Benny Hill, Harry Secombe, Dick Emery, Bernard Bresslaw, Hattie Jacques, and Bruce Forsyth – together with a young Julie Andrews as Archie’s girlfriend. Imagine this radio programme being the start of your career! If you feel strong enough, listen to a clip of the programme in 1951.

It says a lot about where we were so many years ago – the Dark Ages of humour. But there is a string of equally awful entertainment on the radio and TV which kept people home.

And then all of a sudden, Harry and Meghan announce the name of their first child: Archie Harrison Mountbatten-Windsor he is and heaven help him.

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40 Years

Margaret Thatcher became Prime Minister on 4 May 1979, the day I left the UK to start my new job at Shell Research in Amsterdam. I had packed what I needed for a month into my car and took the Sealink overnight ferry from Harwich to The Hoek of Holland. As the boat left Harwich, I made my way to the 1st class restaurant at the rear of the boat and looked out as the UK slowly became smaller and smaller. To celebrate I had ordered a bottle of the best red wine. I was happy.

Now just imagine someone joining me at my table and telling me what would happen to me in the 40 years to come. And this is more or less what this blog is all about, not the actual things which happened ( you can read all this in the 700 plus blogs I have written) but the context and emotions during this time. I would be living in The Hague with my Dutch girlfriend whom I had met in New York in 1974. She was a lawyer doing a Masters Degree at Columbia and I was starting my second PostDoc. We were both residents in the Kings Crown hotel, as were many other students who did not realise how expensive it was! The first thing she said to me was “I have a boyfriend” which meant we enjoyed each other’s company for a year and no more than that. She left to return to the Netherlands and I went on to California and my first real job.

My stay in California was a lot shorter than planned (see Syva blogs) and Shell was happy that I finally accepted their job offer of 1974, placing me in a UK research agrochemical laboratory and not the Amsterdam which I wanted. In 1977 my girlfriend became my girlfriend during a one week stay in The Hague on the Senior Staff introduction course. After bitching that I wanted to work for Shell in Amsterdam, they finally let me go there on a one-year exchange program. Not only that but I would be on an ex-pat salary meaning my take-home pay was about twice that of my colleagues! The only disadvantage was having to commute every day, firstly by train (Shell provided a 1st class season ticket) and later by car (after I was fed up with the train and my fellow passengers).

For four years I worked in a pure research unit, a sort of playground for academically orientated researchers such as I was with no real accountability. Eventually my boss advised me to switch to applied research if I wanted any career. My one year exchange program had been extended annually all this time and I had become very comfortable financially. In applied research I landed with a “thump” and awoke to the reality of what applied research was all about. There was a catalyst which had only 10% of the activity required to make the process economic – my job was to achieve just that. As a pure scientist I earned the contempt of all around me until the day I showed that my pure approach had delivered Shell with their commercial catalyst.

That was the beginning of the end. My bosses were relentless and made my job hell. So I quit, not something that often happened, and formed my own company which would provide industrial companies with the chemicals prepared in academic research. To make the Shell catalyst active enough, I was eventually allowed to commission a short research project at a local university to prepare a key ingredient. In pure research, I could have easily done this myself but now in the applied laboratory which did not have the right equipment. It was unheard of for one division to help another which I shall come back to shortly.

It was at this time that my long-term relationship with my girlfriend ended. She wanted to become a career diplomat and I wanted to stay in The Hague.

My new company was called Specs (Speciality Chemicals Services) and the idea was that industrial researchers could ask us to have academics prepare the materials not to be found in commercial catalogues. I had a sizeable academic network which I had built and maintained over the ten or more years at Shell but, even so , the business was simply too high-risk to make a profit. It was after 2.5 years and nearing bankruptcy that Pfizer, the American pharmaceutical giant, discovered us and the whole business model changed.

Within a year we had huge contracts to deliver random selections of very small amounts of academic research chemicals, each contract was prepaid in full and I started to build the supplier network throughout Europe and the disintegrating Soviet Union. We recruited a lot of staff, mostly fresh university graduates, and moved offices three times to absorb the growing numbers.

I had married in 1989 and we had three children (Lisa, 1990, Christy, 1991 and Guus, 1993). I was travelling the world on sales and acquisition campaigns which took me away for roughly half the year. It all seemed to be going so well which, in retrospect, it exactly the time to start worrying.

Two members of the Management Team started their own competing company taking with them the profitable supplier and customer networks. The company was forced to downsize and in 2003 I separated from my wife. This was tough on my children and I did my best to be with them when I could. I started a Foundation (Kids and Science) to inspire young people to think creatively as well as founding a new company (SORD) to collect and distribute synthetic methods, data from academic theses and dissertations. This meant working very long days, no vacations and doing all I could for my children. My wife died from a horrible cancer in 2010.

Now we skip to today. Lisa married Dylan in 2017 and in September 2018 Bobbie Martine was born, my first grandchild. In January Christy moved to Amsterdam to live with he boyfriend Diederik. Guus now has a wonderful girlfriend as well as his Masters Degree in Law. Take a look at the young happy faces in Amsterdam a couple of weeks ago.

Now to context. In 1979 I was embarrassingly arrogant. I featured in a video commissioned by Shell to highlight the careers of a Department Head, a Section Head and a researcher (me). It takes a lot of courage for me to look at this video! The video crew even shot more (awful) film at my home in 1984 – do not watch this if you have just eaten!

At Specs I profited from the war between pure and applied research at Shell. What pure research had ordered a month before was then re-ordered by applied research – no way that one division would consider helping the other. I had escaped from a research facility where the Dutch Reformed Church exerted such power. In spite of this Shell went from strength to strength. The ag-chem business where I had started in 1976 was closed down not long after I had left. It contributed only 1% to Shell’s total turnover and it was a few years later that most UK research (chemicals) was moved overseas. The bean-counters kept striking.

Shell still makes promotional videos; the labs where I worked were closed and relocated to a new site, with all sorts of odd companies taking over the buildings where I once worked. The first lab I worked in was demolished to make room for the Eye Film museum. I last visited the old site a few years back and I was saddened, shaken even. Even worse, the apartments built on some of the old site have been bought by people who used to work there – how sick can you get? One of my best friends from the time I worked there is still living in Amsterdam and we meet at regular intervals and occasionally talk about the times and the people. He also became a good Specs customer. But he is one of very few; most people I forgot as soon as I could.

At Specs I learned the importance of cash-flow in surviving in business. That too is context. Times change and so do businesses. Pharma research has all but disappeared in the major companies, they buy in leads from small companies and universities. So SORD never really had a chance and, sadder still, academics were very reluctant to have us abstract their theses as a business. In fact, their moronic blindness to the real world still gets more alarming. They are happy to have the university pay millions to get their papers printed and subscribe to the larger publishers. Then, when you tell them they can buy a thesis manuscript for Euro 50 they say you are a thief.

Kids and Science also suffered in the new way of looking at education. It all became centralised and government funded, forcing out initiatives like ours because the money had already been spent elsewhere. Last year we had to admit defeat and close down the Foundation. What really hurt me as a person was having people smile and appear supportive only to do nothing for you the next weeks and months.

So in terms of context, the 40 years contains two great successes and two dismal failures. If the person at my dinner table in 1979 had told me this, what would I have done? Totally stupid question of course. As a scientist you quickly learn to be curious and analytical. In Japan, the director of the agency who sold Specs products became exasperated by my asking continuously what different things in Japan were for. Example: the three lights on the roof of each lorry cab, some alight some not. It had to have some meaning (I thought). But I never stopped asking questions.

Then the personal context. Ten years with my first girlfriend ended and I began thirteen years of marriage ending in divorce and later in the horrible death of my ex-wife. Out of all this I now have three truly remarkable children, now young adults who see the world as I saw it in 1979 – full of opportunity. Their energy and enthusiasm, and their love for me, are the kindest gifts you could ever wish for.

This is a picture from our last vacation as a family, in China in 2011. As much as possible I want them to be free to live their own lives and not to worry about me. Let’s see how I do on that front!

In the 40 years I met so many people, some wonderful and many not so (actually they were stupid). I was fortunate. The good people inspired me so that the stupid ones seemed to disappear. I have mentioned many of these in the older blogs so no need to go back and do that again. I have been cheated by people whom I trusted, I lost every penny I had earned and started from scratch again. Each year the tax man wants even more money so each year there are no vacations. But I have peace now, time to think and to be grateful. After the UK disappeared from view on that ferry in 1979, I went to my cabin and slept very well. The next day I began this fascinating journey…

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The Next Antibiotics

If you go back to my blog of 4 August 2013, I wrote about how medicinal scientists are chasing natural molecules in the oddest of places. The need to find new and effective antibiotics is urgent and good old-fashioned synthetic chemistry is simply too slow. For years, what became Natural Product Chemistry has had its peaks and lows. I still gasp with wonder at the man-years wasted on preparing a complex natural product using synthetic chemistry. Vancomycin and Taxol are but two of a string of (very) complex molecules synthesised by the KC Nicolaou groups. Brevetoxin is for me the absolute winner in complexity.

Incidentally, KC Nicolaou had just left University College London when I arrived to start my PostDoc in 1972; I was initially appalled to find so many bottles labelled KCN in the fridges and freezers (his initials and not the chemical formula for potassium cyanide, the terrible poison).

So what is the newest (desperate) research topic? Fish slime… As ever, The Guardian article provides a very readable story as to why fish slime might be so useful in the antibiotic hunt.

As ever, the closing statement suggests a long time before we might benefit (“However, going from the test tube to a safe and efficacious drug in a patient is only the beginning of a lengthy and costly drug development process.” Now, where have I read that before!

PharmaSea for a start – the multi-multi-million supported program funded by the European Union.  Now that Brexit looks set to happen one day soon, a lot of British scientists might be packing their bags to follow the money. Interesting as ever is the sizeable participation of Italian institutions in projects as well-funded as PharmaSea. If anyone knows how to find money, they do!

So how bad is the situation on effective antibiotics? C&ENews has a fairly recent article. Also try Google searches with keywords such as new antibiotics, etc. But also spare a thought for why bacteria are mutating so fast so that today’s antibiotics so rapidly become ineffective.

A BBC document puts it in everyday language. It points the finger very clearly at us, the idiots who treat antibiotics like aspirins:

Commonly prescribed antibiotics are becoming less effective due to a number of reasons:

  • over use of antibiotics
  • failing to complete the fully prescribed course by a doctor
  • use of antibiotics in farming

These can lead to the effectiveness of antibiotics being reduced, and the incidence of antibiotic resistance increasing. These bacteria are commonly known as superbugs.

Yes, Superbugs…

As a postscript, I recall in the 70’s people said there were more people living than dying because of cancer. Not really funny but it pointed another finger at a crisis producing big research funding eagerly gobbled up by researchers (who warned how long it might take…) I used to be in that crowd a long time ago. Sorry…

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Mr. Guus Lewin Wife LLM

Last week Guus received his Masters diploma (here it is called a “bul”) at a short ceremony which left (for us all) a lasting memory. The young man I wrote about a few blogs ago now starts a new life as a lawyer where he is so very well suited. Who could have expected this? Not me for sure!

So first some pictures of the day and then some thought from me.

The proud family ahead of the ceremony.

Guus getting his “bul”.

Signing the wall (a Leiden tradition).

Posing alongside the famous statues.

Then on to a bar across the road for  a couple of beers, some snacks and then heading home.

How happy I (still) feel. With all three of my children, the high and low times, delight and pain, days when you did not know how to mend lives (but they mended them themselves). No drugs or other nasty problems, it was still a long march. Now it is ending but I am the first to agree that it never ends. For as long as I live I am there (when needed) but hard to find when they are happy with their partners. I never want to be more than that.

So what do I do now? My campaign of some 15 years to help young people discover their own creativity ends in tatters – nobody it seems wants to add their support for their own selfish reasons. The company we founded to process academic theses and dissertations into a database to help chemists discover “lost” chemistry has now been liquidated. No longer any support from industrial or academic so-called researchers. Sad. I need a new challenge and I will find one.

Meanwhile I can enjoy a new life (Bobbie) who has entered my world as a small child and also admire what else my children have to add. These are my thoughts today which I wanted to share with you.

 

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